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Neuropathy involves several processes, such as oxidative stress, inflammation, poor blood flow, high blood sugar, and nerve compression

The Nrf2 pathway, a major antioxidative mechanism in astrocytes, also becomes dysregulated during neurodegeneration

8.3 Mediterranean diet and plant-based dietary patterns The Mediterranean diet, characterized by abundant plant-based foods, olive oil, moderate fish consumption, and red wine, is recognized as one of the healthiest dietary patterns

These analyses reflect fold change from SD- or HFD-fed control animals and were performed using either Excel for Mac (Microsoft Corp.) or Prism v.6 (GraphPad Software)